A (t) Indeed, DNCB is
not sold in pharmacies, as it is a product of organic
chemistry (used in photography).
In the states, it is notably provided by the DNCB treatment
Group : 2261 Market Street # 639, San Francisco, CA 94114,
USA ; email dncbgroup@aol.com ; 25 dollars for a kit to start a
treatment (it includes 4 concentrations), 10 dollars for
each concentration (10%, 2%, 0,2%, 0,02%).
In France, we found the following address : Prolabo, 1 rue
Le Goff, 75005 Paris (Tel : +33 (0)1 44 32 03 21 ; Fax : +33
(0)1 44 32 03 27. We don't know wether this laboratory sells
its products to individuals. This provider doesn't know the
use of DNCB in HIV infection (this laboratory sells chemical
products, not medicine). The DNCB is sold in a non diluted
form, in HIV infection it is only used diluted in aceton or
alcohol.
It appears that the persons to contact first are the members
of the DNCB treatment group.
Concerning its use, these
are the precisions given by Dr Traub (STD Outpatient Unity,
Irmandade da Santa Casa de Misericordia de Porto Alegre, Rua
Santa Terezina 609, 201, Porto Alegre, RS, Brazil, CHP
90040-180 ; Tel : +55 051 223 0047 ; Fax : +55 051 331
6558). DNCB is first used once a week, at the concentration
of 10% until a positive response (signing a sensibilisation)
; then once a week at a concentration of 1 or 2%
(application on a surface of 3 cm2 on the forearm). These
informations are transmitted by Dr Traub in a scientific
communication (Vancouver Conference, Abstract Th. B.4174)
that we summed up and translated on our internet website
<http://www.positifs.org/> (heading
C.22).
In this article, you will
find precisions on its effects, and also in the article of
Dr Striker (450 Sutter Street, Suite 1500, San Francisco, CA
94108, USA ; Tel +1 415 399-1035 ; Fax +1 415 399-1057) who
has worked a long time on the effects of DNCB on cellular
immunity (increase of CD8 lymphocytes, particularly
cytotoxic lymphocytes and natural killers) : J. AM Dermatol
: 1995 ; 33 : 608-611, but also in the article published and
translated in IX 3 (TH B.4182) on our internet website
<http://www.positifs.org/> (heading
C.22).
The aim with an
application of DNCB on the skin, is to provoke an
hypersensibility reaction. This reaction signs the reaction
of some celles of the skin, that make afterwards a contact
with the T4 lymphocytes (DNCB (antigen) presentation in the
lymph nodes). The T4 lymphocytes then proliferate, as well
as the memory cells, wich will be actived at every
application of DNCB, and also an activation of the
macrophages occurs, allowing an increase of the immune
defences against pathogens.
Concerning the use of
DNCB, Billi Goldberg (DNCB treatment Group, BiGoldberg@aol.com), who is working with Dr Striker,
gave precisions in others documents. DNCB mustn't be used
for patients having had an organ transplantation, an active
hepatitis, a pancreatitis, a multiple sclerosis or a
Parkinson disease. A sensibilisation can be made in more or
less long delay. Some recommended to make the first assay
with two applications of 10% DNCB with a few minutes in
between on a surface of 3 cm2 on the forearm. However at
this concentration, when the response is positive (in 10 to
15 days, heat, pruritus). Sensibilisation is sometimes bad
tolerated, and may last more that 4 month (this is maybe why
Dr Traub first uses the 2% concentration). The reaction
after the first sensibilisation is longer to disappear, and
sometimes, is important, so that some patients do not dare
to repeat the experience.
After 15 days, if there is
no intolerance and if there is no sensibilisation, only one
10% application is made every week, until a sensibilisation
appear with the new dose (each time, the application is made
on a different part of the body : arm, leg, thigh, chest).
Once the sensibilisation is obtained, DNCB is then used once
a week at the lowest possible concentration allowing to
activate the reaction (a first assay is carried out at the
0,02 concentration, then 0,2 or 2% the week after). After 15
days, two applications of 2% with a few minutes between are
made every week (in case of failure, the 10% concentration
is used again once a week). (9801)
