CAPRANI A. 1, 2, Richert A. 1, 2, MAURISSON G.1, 3
Association Positifs, BP 230 75865 Paris Cedex 18. E-mail :
2 University 7-Denis Diderot, CNRS Tour 33/34 ESA7057, 2
Place Jussieu, Paris Cedex 05. E-mail :
3 Centre Médical Europe, 44 rue d'Amsterdam, Paris.
E-mail : firstname.lastname@example.org.
prevents TH1 and TH2 imbalance, known to contribute to the
progression of HIV. Moreover, HIV+ patients show generally a
decline of DHEA blood level.
Method: Blood DHEA
sulphate(DHEAS), cortisol, CD4 and CD8 counts were measured
for an HIV+ patient presenting initially a low
DHEAS/cortisol level, during supplementation by 7-keto DHEA
for 16 months
Results : A DHEA
supplementation of a 60 year old osteoporotic patient HIV+
since 20 years, with a stable biological and clinical state
during the preceeding two years (CD4 =325±20/mm3; viral
load< 50 copies/ml; DHEAS ª 700ng/ml; no
opportunistic affections), was instituted in order to
increase mass bone after failure of orthodoxic therapies.
Supplementation was done with 7-keto DHEA (no
hormon-dependent cancer risks); 50mg per os daily the first
3 months and 75mg daily the next 12 months.
After 3 months, blood DHEAS level increases to 1433ng/ml. At
6 and 9 months, DHEAS level increases to 2700ng/ml and then
decreases to 1200ng/ml at 16 months. CD4 increases
progressively, 407 (+24%) at 3 months, 520( +58%) at 6
months and then remains stable 515+/-22. This increase is
highly significant (p<0.05).
In addition, the only biological parameter controlling mass
bone which was drastically disturbed(PTH), was normalized,
despite a contrasting effect on mass bone a the level of the
osteoporotic(L1-L4), which increases drastically of 9,5% at
6 months, but decreases of 18% after 16 months.
Conclusion: Supplementation of DHEA in an HIV+
patient to restore a normal level leads to a drastic
increase of CD4, comparable to that obtained with IL2,
without inducing bone remineralisation able to couterbalance
a well known side effect of HAART. This significant clinical
case justify to undertake a large clinical trial.