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C.57. Toronto 2006: Myelitis AIDS Canarypox and Vaccinia Virus MVA Vaccine PDF print email
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Friday, 05 March 2010 01:17
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AIDS vaccine-induced myelitis: Canarypox virus 005 and spinal cord myelin basic protein molecular homology at sequence GRDSRSGSPMARR with 2 citrullines.



TRAN Mong Ky Guy1*, CAPRANI A.2*

1 University Paris V, Corresp. : 31 Av. du Bois, 92290 Chatenay Malabry, France.
2 University Paris VII, Diderot, Paris, France.
* POSITIFS Association, Paris, France


INTRODUCTION

Canarypox virus based AIDS vaccine was stopped in USA (and also in France) after the occurrence of an acute myelitis case, suggesting that the species barrier between birds and humans (as for influenza and poliomyelitis virus) was broken by canarypox virus. In France, the vaccine did not contain canarypox virus but only lipopeptides, so the vaccination was retried after the verification of lipopeptides innocuity. Zagury D (1991) precedently had complications after vaccination with a vaccinia virus vector in HIV-1 patients, but this was forgotten: He reported cell immunotherapy with recombinant vaccinia that resulted in “wide necrosis” at the site of subcutaneous/intramuscular injections, resulting in death in 3 of 8 Aids patients; all 3 had CD4 counts less than 50 cells/mm3. Thus it seems that poxvirus family may represent a harmful family of viruses in AIDS patients.

In fact the acute myelitis observed with canarypox vaccine reminds the multiple sclerosis (MS) picture and discovery of anti-vaccinia virus antibodies in MS by various authors (Kempe CH, 1973; Thompson JA, 1975; Myamoto H, 1976).

post-vaccinial_myeliltis post-vaccinial_myelitis2 post-vaccinial_myelitis3



Last Updated on Sunday, 14 March 2010 04:13
 
C.48. 5c. 12th International Symposium on HIV & Emerging Infectious Diseases (Toulon 2002) PDF print email
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Friday, 05 March 2010 00:10
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5.c. Molecular homology between Hepatitis C Virus (HCV) core, Hepatitis B Virus (HBV) pre-S1 and Phallotoxin of Amanita phalloides:
Interest of Silymarin of Silybum Marianum.

EXTENDED VERSION /VERSION LONGUE


TRAN M.K.G.*1, KIRKIACHARIAN S.1, MAURISSON G.*2, CAPRANI A.*

* Association Positifs, BP 230, 75865 Paris 18, France. E-mail : This e-mail address is being protected from spambots. You need JavaScript enabled to view it , This e-mail address is being protected from spambots. You need JavaScript enabled to view it .
1 University Paris-Sud, Faculty of Pharmacy, Therapeutic Chemistry, 92290 Chatenay Malabry, France; 31, Av du Bois 92290 Chatenay Malabry, France. E-mail : This e-mail address is being protected from spambots. You need JavaScript enabled to view it .
2 Centre Médical Europe, 44, rue d'Amsterdam, 75009 Paris, France.


INTRODUCTION.

In France, AIDS haemophiliacs and drug addicts and 600,000 patients were infected by HCV, with the risk of cirrhosis and cancer. This constitutes a major health problem. Interferon-alpha and ribavirin could resolve this problem only partially in about 6/10 cases.

No HCV vaccine is available to date.

In Egypt, an epidemics of hepatitis C spread after the mass campaign of emetin intravenous injections with contaminated syringues for bilharsiosis (Schistosomia Mansoni and Haematobium) (Franck C., 2000).


Last Updated on Sunday, 14 March 2010 04:12
 
C.52. EUROCANCER 1998 PDF print email
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Monday, 08 February 2010 05:34
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BRAIN GLIOMA, POLYOMAVIRUS, SV 40-CONTAMINATED ANTI-POLIOMYELITIS VACCINE AND GROWTH FACTORS (EGF, FGF, PDGF, IGF 1).


TRAN Mong Ky Guy*, KIRKIACHARIAN S.**

* University Paris V, Corresp. : 31 Av. du Bois, 92290 Chatenay Malabry
** University Paris XI, Faculty of Pharmacy,92 296 Cedex, Chatenay Malabry, FRANCE.

Background: In HIV patients, progressive multifocal leucoencephalopathy (PML) is characterized by an intense gliosis and caused by a polyomavirus (PV).Brain glioma are induced in newborn hamsters by PV. OHGAKI H (1998) found PV with a high frequency in human glioma. More worrying is the anti-poliomyelitis vaccine contamination by SV 40 in the 1950s., because authentic SV 40 was found in childhood brain tumors. An increase in neural tumors was reported in children born from mothers receiving this vaccine during pregnancy. PV large T (= Tumor) antigen also binds to anti-oncogens p53 and Rb.


Last Updated on Sunday, 14 March 2010 04:12
 
C.51. Bangkok: XVI International Conference on AIDS PDF print email
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Monday, 08 February 2010 05:23
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WePeA5599 Poster

Atherosclerosis and AIDS : Homology between atherogenic Marek's herpes virus and LDL receptor, between cytomegalovirus (CMV) and LDL-related receptor, and between HIV-1 VIF and phospholipase A2.


TRAN Guy Mong Ky ([1], [5]), CAPRANI Adrien ([3], [5]), KIRKIACHARIAN Serge ([2]), MAURISSON Gilbert ([4], [5]).

1 University Paris-Sud XI ; correspondence: 31 Av du Bois, Châtenay-Malabry, France. E-mail : This e-mail address is being protected from spambots. You need JavaScript enabled to view it
2 Therapeutic Chemistry, Faculty Pharmacy, University Paris-Sud XI, Châtenay-Malabry. E-mail : This e-mail address is being protected from spambots. You need JavaScript enabled to view it .
3 University 7-Denis Diderot, CNRS Tour 33/34 ESA7057, 2 Place Jussieu, Paris Cedex 05. E-mail : This e-mail address is being protected from spambots. You need JavaScript enabled to view it .
4 Centre Médical Europe, 44 rue d'Amsterdam, Paris. E-mail : This e-mail address is being protected from spambots. You need JavaScript enabled to view it .
5 Association Positifs, BP 230 75865 Paris Cedex 18. E-mail : This e-mail address is being protected from spambots. You need JavaScript enabled to view it

Aids is characterized by the occurrence of severe atherosclerosis in very young patients. This prompted us to look for the physiopathology of atherosclerosis in this especially susceptible but unusual population. Our objective is to screen for viruses inducing atherosclerosis.

We looked on Marek's herpes virus (Fabricant C.G., 1978), which can induce in chicken coronary disease even with a diet without cholesterol. CMV is also a good candidate, as it enhances the recurrences of coronary stenosis after stent. Lastly, in transgenic mouse, phospholipase A2 is responsible of atherosclerosis (Ivandic B., 1999). By comparison of amino acid sequences, we found 3 significant homologies :

  1. Marek's herpes virus 132bp repeat (sequence LHTS... TICRNK FLCLLP) ...is a rabbit LDL cholesterol receptor ( repeat V)-like (CIHSSÉSLC-ss-CKNK... RQFVC-ss-CPVL) in tridimensional cysteine bridged [-ss-] structure.
  2. CMV TRL6 (sequence WKTV...DQWLCNVTGIGNAT) is a LDL related receptor-like. (WHSV...QWLCD).
  3. HIV-1 VIF protein has the tridimensionnal structure and active site residues (His, Ser) of a phospholipase A.

Conclusion:

These striking homologies between virus and cholesterol receptors, and between HIV-1 VIF and phospholipase A may explain the abnormal occurrence of severe atherosclerosis in such a young population as AIDS. Treatment must focus on anti-herpes virus drugs (and bee propolis, an antiviral natural product) as well as on VIF for a component of AIDS vaccine and anti-phospholipase drug.


Last Updated on Sunday, 14 March 2010 04:16
 
C.50a. Toulon 2004 PDF print email
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Monday, 08 February 2010 04:28
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13th International Symposium on HIV & Emerging Infectious Diseases


For all abstracts: http://www.isheid.com/



MOLECULAR HOMOLOGY BETWEEN ALPHA-DEFENSIN AND SCRUB TYPHUS RICKETTSIA ORIENTIA TSUTSUGAMUSHI 56K TYPE SPECIFIC ANTIGEN

Authors : TRAN M.K.G.[1], [5], KIRKIACHARIAN S.[2], MAURISSON G.[3], [5], CAPRANI A.[4], [5]

1 University Paris-Sud XI ; correspondence: 31 Av du Bois, Châtenay-Malabry, France.
2 Therapeutic Chemistry, Faculty Pharmacy, University Paris-Sud XI, Châtenay-Malabry.
3 Centre Médical Europe, 44 rue d'Amsterdam, Paris
4 CNRS UMR, University 7-Denis Diderot, CNRS UMR 7057, 2 Place Jussieu, Paris Cedex 05.
5 Association Positifs, BP 230 75865 Paris Cedex 18.


INTRODUCTION

The challenge of an HIV vaccine is not yet solved, but new areas were appearing with advances coming from unexpected directions, such as amelioration of HIV infection in some (about 40%) but not all patients infected by scrub typhus in Thailand (Watt G., 2001, 2000). In the same time, elucidation of the mysterious protective factor in long-term nonprogressors conducted to the discovery of a-defensin (Zhang L., 2002). The crucial Nef protein was in fact an a-defensin-like homolog (Tran M.K.G., 2003). What became evident then is the strength of molecular mimicry as an unique method for unifying these 3 discoveries, at the level of amino acid sequences (as we shall see further), at the cross road of these 3 apparently independent data.

Last Updated on Sunday, 14 March 2010 04:16
 


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